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autologous epstein-barr virus-specific cytotoxic t lymphocytes (Nantes University Hospital)
- Development stage
- Unknown
- Lead developer
- Nantes University Hospital
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
Autologous Epstein-Barr virus-specific cytotoxic T lymphocytes (EBV-specific CTLs) is an investigational adoptive cell therapy developed by Centre Hospitalier Universitaire de Nantes (Nantes University Hospital). The therapy involves the ex vivo expansion of a patient's own T lymphocytes to specifically target and eliminate cells infected with the Epstein-Barr virus (EBV), focusing on antigens such as EBNA1, LMP1, and LMP2A. The biological rationale is based on the hypothesis that a deficiency in CD8+ T cell-mediated immune surveillance of EBV allows EBV-infected autoreactive B cells to accumulate and drive the pathogenesis of multiple sclerosis (MS). By restoring this immune surveillance, the therapy aims to reduce disease activity in patients with MS and clinically isolated syndrome (CIS).
- Other names
- autologous EBV-specific CTLsEBV-specific CTLsEBV-specific cytotoxic T lymphocytes
02
Targets
Epstein-Barr virus Latent Membrane Protein 2A-derived peptide–Human Leukocyte Antigen complexespMHC-I (Peptide–MHC class I complex)pMHC (Peptide-MHC complex family)
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