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autologous fecal microbiota transplantation (Women's College Hospital)
- Development stage
- Unknown
- Lead developer
- Valerie Taylor
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Cell Therapies, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Rectal
01
Overview
Autologous fecal microbiota transplantation (FMT) is an experimental biologic therapy being investigated as a placebo control in a clinical trial for the treatment of bipolar depression. The intervention is part of a randomized, double-blind study (NCT03279224) led by Dr. Valerie Taylor, comparing it against allogenic FMT (using stool from healthy donors). [1, 6, 7] The procedure involves collecting a patient's own stool, processing it, and re-administering it via colonoscopy. [6, 9] The underlying mechanism of action being tested is the modulation of the gut microbiome to influence mental health through the gut-brain axis. [2, 6] This pilot study aims to evaluate the feasibility, safety, and efficacy of manipulating the gut microbiota as an adjunctive treatment for individuals with treatment-resistant bipolar depression. [6, 7]
- Other names
- autologous FMT
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