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autologous hematopoietic stem cells (Cedars-Sinai Medical Center)
- Development stage
- Unknown
- Lead developer
- Cedars-Sinai
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Autologous hematopoietic stem cells (HSCs) are being utilized in a specialized therapeutic protocol developed by Cedars-Sinai Medical Center for the treatment of refractory Crohn's disease. This cell therapy involves a multi-step process: first, the patient's own stem cells are mobilized and collected from the peripheral blood; second, the patient undergoes a conditioning regimen of high-dose immunoablation (typically using cyclophosphamide, fludarabine, and anti-thymocyte globulin) to deplete the existing, dysfunctional immune system; and finally, the harvested HSCs are re-infused. The therapeutic goal is to reset the immune system, allowing for the development of a new, self-tolerant immune repertoire that can lead to long-term clinical remission in patients who have failed standard biologic and immunosuppressive therapies.
- Other names
- autologous hematopoietic stem cell transplantationHSCTPeripheral Blood Stem Cell InfusionPBSC
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