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autologous hematopoietic stem cells (Makati Medical Center)
- Development stage
- Unknown
- Lead developer
- Makati Medical Center
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Autologous hematopoietic stem cell transplantation (AHSCT) is a cellular therapy being investigated by the Makati Medical Center for the treatment of multiple sclerosis (MS). The procedure involves the mobilization and collection of a patient's own hematopoietic stem cells, followed by a reduced-intensity immunoablative conditioning regimen known as BEAM (carmustine, etoposide, cytarabine, and melphalan). This chemotherapy regimen is designed to deplete the patient's existing, autoreactive immune system. Subsequently, the harvested stem cells are reinfused into the patient to facilitate the reconstitution of a new, functional immune system that lacks the pathogenic memory cells responsible for MS progression. This specific protocol is being evaluated in a Phase 1, patient-sponsored clinical trial (NCT03113162) targeting patients with progressive forms of the disease.
- Other names
- AHSCTAutologous Hematopoietic Stem Cell TransplantationReduced-intensity BEAM followed by AHSCT
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