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autologous mesenchymal stromal cells (Fundación Instituto de Ciencias de la Salud de Castilla y León)
- Development stage
- Unknown
- Lead developer
- Fundación Instituto de Ciencias de la Salud de Castilla y León
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intraarticular
01
Overview
**Autologous mesenchymal stromal cells** are a patient-specific, culture-expanded bone marrow-derived mesenchymal stromal cell therapy being developed by Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León for intra-articular treatment of knee osteoarthritis. In the Phase III ARTROCELL study, the investigational product is administered as a single intra-articular knee injection and is evaluated against allogeneic bone marrow-derived mesenchymal stromal cells and hyaluronic acid. The therapeutic rationale is that MSCs can exert local paracrine immunomodulatory, anti-inflammatory, trophic, and tissue-homeostasis effects within the osteoarthritic joint; however, no single molecular target or clinically established cartilage-regeneration mechanism has been defined for this product.
- Other names
- autologous bone marrow-derived mesenchymal stromal cellsautologous MSCsautologous BM-MSCs
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