autologous platelet gel (Centre Hospitalier Universitaire de Nice)

Autologous platelet gel (APG), often referred to as platelet-rich fibrin (PRF) or platelet-rich plasma (PRP) gel, is a concentrated suspension of platelets and growth factors derived from a patient's own blood. It is produced by centrifuging whole blood to isolate the platelet-rich fraction, which is then activated (often with thrombin or calcium) to form a gel-like fibrin matrix. This matrix serves as a scaffold that slowly releases bioactive proteins, including vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), and various cytokines (IL-1, IL-6, TNF-α). These factors promote angiogenesis, cell proliferation, and collagen synthesis, thereby accelerating wound healing and tissue regeneration. It is primarily used in postoperative wound care, orthopedic surgery, and dental procedures.

Other names

platelet-rich fibrinplatelet-rich plasma gelautologous platelet-rich fibrinautologous platelets gel