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Avène Cleanance Comedomed+ is a topical dermo-cosmetic skincare treatment developed by Laboratoires Dermatologiques Avène (a division of Pierre Fabre) for oily, acne-prone, and blemish-prone skin. It is formulated as a lightweight gel-cream containing 25% Comedoclastin™ (a patented plant extract derived from milk thistle, *Silybum marianum*) and 4% Niacinamide, enriched with Avène Thermal Spring Water. The product targets the formation of microcomedones and micro-inflammation to prevent and reduce blackheads, whiteheads, pimples, and post-acne marks. It is suitable for teenagers and adults, including pregnant women, and has demonstrated anti-relapse efficacy for up to one year.
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