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AZD0466 + voriconazole
- Development stage
- Unknown
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
AZD0466 + voriconazole is an investigational drug combination studied primarily to evaluate the safety and pharmacokinetics of AZD0466, a dual BCL2/BCL-XL inhibitor, when co-administered with voriconazole, a triazole antifungal commonly used for prophylaxis or treatment of fungal infections in immunocompromised patients. AZD0466 is a dendrimer-conjugated prodrug of the small molecule AZD4320, designed to inhibit anti-apoptotic proteins BCL2 and BCL-XL, key regulators of cancer cell survival in hematological malignancies. The combination is being evaluated to assess potential drug-drug interactions and tolerability in patients who may require both agents during cancer therapy.
- Other names
- AZD0466 and voriconazoleAZD-0466 and voriconazoleAZD 0466 and voriconazole
02
Targets
BCL2L1 (B-cell lymphoma-extra large protein)
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