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AZD4041 + morphine
- Development stage
- Discontinued
- Lead developer
- Eolas Therapeutics
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
AZD4041 + morphine refers to the combined administration of AZD4041 (an oral small molecule, orexin 1 receptor antagonist developed by AstraZeneca for the treatment of opioid use disorder and studied for its effect on mitigating respiratory depression when co-administered with morphine) and morphine (a classical opioid analgesic acting primarily as a mu opioid receptor agonist). This combination is under clinical investigation to evaluate whether AZD4041 can counteract morphine-induced respiratory depression while both drugs are present in the system. Clinical studies have been conducted in healthy recreational opioid users to assess safety, respiratory drive, and pharmacodynamic effects[1][3].
- Brand names
- Duramorph PF
- Other names
- AZD4041 + morphine
02
Targets
MOR (Mu opioid receptor)HCRTR1 (Orexin/hypocretin receptor type 1)
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