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AZD4635 + abiraterone acetate

Development stage: Preclinical
Lead developer: AstraZeneca
Modality: Small Molecules
Administration: Oral

Overview

AZD4635 + abiraterone acetate is an investigational combination of two pharmaceutical agents used in oncology. **AZD4635** is a selective antagonist of the adenosine A2A receptor, designed to counteract the immunosuppressive effects of adenosine in the tumor microenvironment and promote anti-tumor immunity, especially relevant for metastatic castration-resistant prostate cancer[1][2][3][5]. **Abiraterone acetate** is a CYP17A1 inhibitor that blocks androgen biosynthesis and is approved for treating prostate cancer[4]. The combination aims to leverage immunomodulation (via AZD4635) alongside androgen deprivation (via abiraterone acetate) for potential improved antitumor efficacy.

Brand names: Zytiga

Targets

ADORA2A (Adenosine A₂A Receptor)ADORA1 (Adenosine receptor A1 subtype)ADORA3 (Adenosine A3 receptor)ADORA2B (Adenosine A2B receptor)CYP17A1 (Steroid 17-alpha-hydroxylase/C17,20 lyase)

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