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AZD5305 + apalutamide
- Development stage
- Phase 2
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
AZD5305 + apalutamide is an investigational oral combination therapy being studied for metastatic prostate cancer. AZD5305 is a next-generation, selective PARP1 inhibitor, designed to block the activity of PARP1, an enzyme involved in DNA damage repair, thereby promoting cancer cell death. Apalutamide is an oral androgen receptor inhibitor that blocks androgen signaling to inhibit prostate cancer growth. The combination aims to enhance anti-tumor efficacy by attacking two complementary pathways: DNA damage repair and androgen receptor signaling. The primary indication being studied is metastatic prostate cancer, including both castration-resistant and castration-sensitive forms. The regimen is in clinical trials for safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy[1][3][5].
- Other names
- AZD5305AZD-5305AZD 5305apalutamide
02
Targets
AR (Adrenergic receptors)PARP1 (Poly (adp-ribose) polymerase 1)Pol II (RNA polymerase II elongation factors)
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