Drug intelligence / Profile preview

AZD5423 + formoterol

Development stage
Unknown
Lead developer
AstraZeneca
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation
01

Overview

**AZD5423 + formoterol** is a combination of two inhaled medications under investigation for respiratory conditions, primarily **chronic obstructive pulmonary disease (COPD)**. **AZD5423** is a novel inhaled, selective glucocorticoid receptor modulator (SGRM) developed to reduce airway inflammation with potentially fewer systemic side effects compared to traditional corticosteroids. **Formoterol** is a long-acting beta2-adrenergic receptor agonist (LABA), already widely used in asthma and COPD as a bronchodilator to relax bronchial smooth muscle and improve airflow. In trials, patients received **AZD5423** on a background therapy of formoterol to assess efficacy and safety in COPD. As of current knowledge, AZD5423 + formoterol has been studied in phase 2 clinical trials and is not yet approved for any indication.

02

Targets

GR (Glucocorticoid receptor)ADRB2 (β2)ADRB3 (β3)ADRB1 (β1)

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