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azithromycin + dexamethasone
- Development stage
- Phase 3
- Lead developer
- InSite Vision
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Ophthalmic, Topical
01
Overview
Azithromycin + dexamethasone is a fixed-dose combination of two pharmaceutical agents used primarily in the treatment of conjunctivitis and blepharoconjunctivitis. Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, thereby preventing the growth and spread of bacteria. Dexamethasone is a synthetic corticosteroid that suppresses inflammation by inhibiting chemical mediators such as prostaglandins and leukotrienes. The combination leverages both antibacterial and anti-inflammatory actions to treat infections and reduce associated ocular inflammation[1][2][4][5][6].
- Other names
- azithromycin/dexamethasone
02
Targets
Bacterial 50S ribosomal subunitGR (Glucocorticoid receptor)
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