azithromycin + insulin lispro + dietary support

The AIDIT protocol (Azithromycin Insulin Diet Intervention Trial) is a combination therapy regimen developed by Uppsala University for the treatment of newly diagnosed Type 1 Diabetes Mellitus (T1D) in children. The protocol consists of the macrolide antibiotic azithromycin, intensified insulin treatment using insulin lispro, and dietary counseling. The therapeutic rationale is based on the hypothesis that bacterial infections may trigger or exacerbate the autoimmune destruction of pancreatic beta cells. Azithromycin is administered to eliminate potential infectious triggers, while intensified insulin therapy is used to induce 'beta-cell rest' and preserve endogenous insulin production. Dietary support is provided to promote habits that minimize bacterial reflux from the duodenum to the pancreatic duct, further protecting beta-cell function.

Brand names

AzithromaxHumalog

Other names

Azithromycin Insulin Diet Intervention TrialAIDIT