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This is a combination of three active pharmaceutical ingredients: - **Azithromycin** is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, used to treat various bacterial infections. - **Rivaroxaban** is an oral anticoagulant that selectively inhibits Factor Xa, interrupting the intrinsic and extrinsic pathway of the blood coagulation cascade. It is indicated for prevention and treatment of thromboembolic disorders such as deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke prevention in nonvalvular atrial fibrillation. - **Paracetamol** (also known as acetaminophen) is a non-opioid analgesic and antipyretic agent used for relief of mild-to-moderate pain and fever. Its mechanism involves inhibition of prostaglandin synthesis in the central nervous system. There are no known fixed-dose combination products containing all three agents together; this listing refers to their concurrent use rather than a marketed co-formulation. Coadministration may present significant drug-drug interaction risks, particularly between azithromycin and rivaroxaban due to increased bleeding risk[1][3][4]. Paracetamol does not have significant interactions with either agent but should be used within recommended dosing limits[2][5][9].
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