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Bacillus coagulans + chitosan
- Development stage
- Preclinical
- Lead developer
- Kafkas University
- Modality
- Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Bacillus coagulans + chitosan is a synbiotic formulation combining the spore-forming probiotic bacterium *Bacillus coagulans* with the prebiotic polymer chitosan (or its derivative, chitooligosaccharide). This combination is designed to act synergistically to restore gut microbiota homeostasis, enhance intestinal epithelial barrier integrity, and modulate immune responses. In preclinical models of ulcerative colitis, the synbiotic formulation has demonstrated therapeutic potential by preserving crypt architecture, maintaining goblet cell density, reducing pro-inflammatory cytokines (such as IL-6 and IL-8), and promoting the recovery of short-chain fatty acids (SCFAs) and tight junction proteins.
- Other names
- Bacillus coagulans + chitooligosaccharidesBacillus coagulans and chitooligosaccharidesBacillus coagulans and chitosan
02
Targets
IL10 (Interleukin-10)IL-6 (Interleukin 6)OmpA (Outer membrane protein A)Zonulin
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