Drug intelligence / Profile preview

bacitracin + cefazolin + gentamicin

Development stage: Unknown
Lead developer: Bacillus licheniformis (original source)
Modality: Small Molecules
Administration: Surgical Irrigation, Topical

Overview

A combination antibiotic solution used for surgical irrigation, particularly in procedures such as breast implant surgery and cardiac surgery. The standard formulation typically consists of 50,000 units of bacitracin, 1 gram of cefazolin, and 80 mg of gentamicin in 500 mL of normal saline. This combination creates a synergistic effect against a wide range of bacteria that could potentially cause surgical site infections.

Other names: Triple Antibiotic SolutionTAS

Targets

Bacterial RibosomeC55-PP (Undecaprenyl pyrophosphate)PBP (Penicillin-binding protein family)

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