Bacitracin + Lidocaine + Polymyxin B

The combination of polymyxin B, bacitracin, and lidocaine is a topical antibiotic medication with pain relief properties. It's commonly used to prevent infections in minor skin injuries such as cuts, scrapes, and burns[1][2]. This medication is available over-the-counter in the United States[7]. ## Composition and Mechanism This combination contains three antibiotics (polymyxin B, bacitracin, and neomycin) plus lidocaine, which provides pain relief[1][3]. Each component has a specific function: - **Bacitracin**: Prevents formation of bacterial protective covering essential for bacterial survival[5] - **Lidocaine**: Acts as a local anesthetic by blocking pain signals from nerves to brain, decreasing pain sensation and skin irritation[5] - **Polymyxin B**: Kills bacteria by destroying the bacterial cell membrane[5]

Brand names

Neosporin Plus Maximum StrengthFirst Aid Triple Antibiotic with Pain RelieverProCoMycinSx1 Medicated Post-Operative SystemSx-1 Medicated Post-Operative SystemSx 1 Medicated Post-Operative System