Drug intelligence / Profile preview

bacitracin zinc + hydrocortisone + polymyxin b sulfate + neomycin sulfate

Development stage
Approved
Lead developer
Bausch & Lomb
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

A **topical ophthalmic combination drug** containing **bacitracin zinc, hydrocortisone, polymyxin b sulfate, and neomycin sulfate** formulated as a sterile ophthalmic ointment. It combines **broad-spectrum antibacterial activity** from neomycin, polymyxin B, and bacitracin with the **anti-inflammatory corticosteroid** activity of hydrocortisone, and is used for **steroid-responsive inflammatory ocular conditions** in which bacterial infection is present or there is a meaningful risk of bacterial infection. Labeled uses include inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe, chronic anterior uveitis, infective conjunctivitis, and corneal injury from chemical, radiation, or thermal burns or foreign-body penetration. This is an established **small-molecule ophthalmic anti-infective plus corticosteroid combination**, historically marketed under names such as **AK-Spore H.C.** and also available as generic ophthalmic ointment products.

Brand names
AK-Spore H.C.
Other names
neomycin sulfate + polymyxin b sulfate + bacitracin zinc + hydrocortisone ophthalmic ointmentneomycin and polymyxin b sulfates + bacitracin zinc + hydrocortisone ophthalmic ointmentbacitracin zinc + hydrocortisone + polymyxin b sulfate + neomycin sulfate
02

Targets

C55-PP (Undecaprenyl pyrophosphate)Bacterial RibosomeGR (Glucocorticoid receptor)

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