bacitracin zinc + hydrocortisone acetate + polymyxin b sulfate + neomycin

Bacitracin zinc + hydrocortisone acetate + polymyxin b sulfate + neomycin is a four-component **ophthalmic ointment** that combines three topical antibiotics with a corticosteroid for steroid-responsive inflammatory ocular conditions in which bacterial infection is present or there is a meaningful risk of bacterial infection. The antibiotic components provide complementary antibacterial coverage: **bacitracin zinc** interferes with bacterial cell wall synthesis, **polymyxin b sulfate** disrupts bacterial cell membrane integrity, and **neomycin** is an aminoglycoside that inhibits bacterial protein synthesis by binding the 30S ribosomal subunit; **hydrocortisone acetate** activates the glucocorticoid receptor to suppress ocular inflammation, edema, and immune signaling. The product has been marketed as **Cortisporin Ophthalmic Ointment** and **Neo-Polycin HC Ophthalmic Ointment**, and has been associated historically with **Pfizer**. It is used for inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe, including chronic anterior uveitis, infective conjunctivitis, and corneal injury from chemical, radiation, or thermal burns or foreign-body penetration when antibacterial coverage is warranted.

Brand names

Cortisporin Ophthalmic OintmentNeo-Polycin HC Ophthalmic Ointment

Other names

neomycin + polymyxin b sulfate + bacitracin zinc + hydrocortisone acetateneomycin and polymyxin b sulfates and bacitracin zinc with hydrocortisone acetate ophthalmic ointment