Drug intelligence / Profile preview

bacitracin zinc + lidocaine hydrochloride + polymyxin b sulfate + neomycin

Development stage
Approved
Lead developer
Trifecta Pharmaceuticals
Modality
Small Molecules
Administration
Topical
01

Overview

This drug is a **topical combination small-molecule product** containing **bacitracin zinc, polymyxin b sulfate, neomycin, and lidocaine hydrochloride**. The three antibacterial components provide broad first-aid topical anti-infective coverage: bacitracin inhibits bacterial cell wall synthesis, polymyxin b disrupts the outer membrane of susceptible gram-negative bacteria, and neomycin, an aminoglycoside, inhibits bacterial protein synthesis at the 30S ribosomal subunit. Lidocaine hydrochloride is a local anesthetic that blocks voltage-gated sodium channels to reduce pain at the site of application. Publicly verifiable labeling supports this combination as an OTC topical ointment marketed for prevention of infection and temporary pain relief in minor cuts, scrapes, and burns; a specific painful urethritis use appears to reflect lidocaine jelly labeling rather than a clearly verified public source for this exact four-ingredient combination.

Brand names
Triple Antibiotic Plus Lidocaine
Other names
bacitracin zinc + lidocaine hydrochloride + polymyxin b sulfate + neomycinbacitracin zinc + neomycin sulfate + polymyxin b sulfate + lidocainetriple antibiotic plus lidocaine
02

Targets

C55-PP (Undecaprenyl pyrophosphate)Mitoribosome (Mitochondrial ribosome)Bacterial RibosomeIDE (Insulin-degrading enzyme)A2M (Alpha-2-macroglobulin)NaV (Voltage-gated sodium channels)LPS/PL (Bacterial outer membrane lipopolysaccharide and phospholipid)

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