Drug intelligence / Profile preview

bacitracin zinc + polymyxin b

Development stage
Approved
Lead developer
Bausch + Lomb
Modality
Small Molecules
Administration
Ophthalmic, Topical
01

Overview

Bacitracin zinc + polymyxin b is a fixed-dose **ophthalmic antibiotic combination** used topically for superficial bacterial infections of the external eye and its adnexa, including conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, and blepharoconjunctivitis caused by susceptible organisms. The product combines bacitracin zinc, a cyclic polypeptide antibiotic that inhibits bacterial cell wall synthesis, with polymyxin b, a polypeptide antibiotic that disrupts bacterial cell membrane integrity, providing complementary Gram-positive and Gram-negative antibacterial coverage. It is marketed as an ophthalmic ointment, including under the brand name Polycin, and has been associated with manufacturers such as Bausch & Lomb, Akorn, and Fougera.

Brand names
Polycin
Other names
bacitracin zinc and polymyxin b sulfate ophthalmic ointmentbacitracin zinc + polymyxin b sulfatebacitracin zinc + polymyxin b ophthalmic ointment
02

Targets

A2M (Alpha-2-macroglobulin)IDE (Insulin-degrading enzyme)C55-P (Undecaprenyl phosphate (Bactoprenol phosphate))LPS/Phospholipids (Gram-negative bacterial membrane lipids (Lipopolysaccharide and Phospholipids))

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