baclofen + memantine

**baclofen + memantine** is a combination of the two marketed drugs, baclofen (a GABAB receptor agonist, used primarily as a muscle relaxant for spasticity) and memantine (an NMDA receptor antagonist, approved for moderate to severe Alzheimer's disease)[3][9]. The combination has been studied for safety and tolerability in healthy volunteers, and has been proposed for use in treating overweight, obesity, or related symptoms, as well as for weight reduction[9]. There is a documented patent proposing this combination for these indications, where both agents are administered together or sequentially, preferably within a short time window[9]. However, no unique brand or trade name is associated with the combination, and it is not widely marketed as a formulation. Both drugs act on the central nervous system via distinct mechanisms: baclofen activates inhibitory GABAB receptors, while memantine is a noncompetitive antagonist at NMDA-type glutamate receptors, reducing excitatory neurotoxicity and abnormal activity[1][2][6][9].

Other names

baclofen and memantine combination