Drug intelligence / Profile preview

bacopa monnieri + nardostachys jatamansi

Development stage
Unknown
Lead developer
Stanley Medical Research Institute
Modality
Small Molecules
Administration
Oral
01

Overview

This water-based herbal combination, developed by The Stanley Medical Research Institute, consists of extracts from *Bacopa monnieri* (BM) and *Nardostachys jatamansi* (NJ). It was investigated as an oral treatment for schizophrenia, with the hypothesis that it would provide comparable efficacy to modern atypical antipsychotics like olanzapine while maintaining a superior safety profile for long-term use. *Bacopa monnieri* is traditionally recognized in Ayurvedic medicine for its potential to repair damaged neurons by enhancing kinase activity and nerve impulse transmission, alongside its antioxidant properties. *Nardostachys jatamansi* contributes neuroprotective and potentially sedative effects. The combination was evaluated in a Phase 2 clinical trial (NCT00483964) to assess its safety and efficacy in managing schizophrenia symptoms.

Other names
BM + NJ combinationSMRI herbal combinationAyurvedic herbal preparation
02

Targets

PK (Pyruvate kinase)

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