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Basel cocktail + rifampicin

Development stage: Unknown
Modality: Small Molecules
Administration: Oral

Overview

The Basel cocktail + rifampicin is a combination used in clinical pharmacology research to study drug-drug interactions and cytochrome P450 (CYP) enzyme activity. The Basel cocktail is a phenotyping tool containing six probe drugs (caffeine, efavirenz, flurbiprofen, metoprolol, midazolam, and omeprazole), each targeting specific CYP enzymes. Rifampicin is a potent CYP enzyme inducer that significantly affects drug metabolism. When administered together, researchers can assess how rifampicin's enzyme-inducing properties affect the metabolism of the cocktail components, providing valuable information about drug interactions and metabolic pathways.

Other names: Basel phenotyping cocktail + rifampicinBasel cocktail + rifampin

Targets

CYP2C19 (Cytochrome P450 2C19)PXR (Pregnane X receptor)CYP1A2 (Cytochrome P450 1A2)CYP3A4 (Cytochrome P450 3A4)CYP2B6 (Cytochrome P450 2B6)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)

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