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basimglurant + carbamazepine
- Development stage
- Phase 1
- Lead developer
- Noema Pharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**basimglurant + carbamazepine** is an experimental drug combination consisting of basimglurant (INN: basimglurant, development code names RO4917523, RG-7090) and carbamazepine. Basimglurant is a selective negative allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5). It was developed by Roche and Chugai Pharmaceutical as a potential adjunctive therapy for treatment-resistant depression and fragile X syndrome, with its primary mechanism being the inhibition of mGlu5-mediated glutamatergic signaling. Carbamazepine is a voltage-gated sodium channel blocker widely used as an anticonvulsant, mood stabilizer, and analgesic for trigeminal neuralgia. The combination has been studied in healthy volunteers to assess pharmacokinetic interactions, with carbamazepine known to induce hepatic enzymes that can accelerate the metabolism of other drugs, including potential interactions with basimglurant[1][2][5][8].
- Other names
- basimglurant + carbamazepine
02
Targets
GRM5 (Metabotropic glutamate receptor 5)SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)
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