Drug intelligence / Profile preview

BAT1308 + carboplatin + paclitaxel

Development stage
Unknown
Lead developer
Bio-Thera Solutions
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

**BAT1308 + carboplatin + paclitaxel** is a combination regimen of a monoclonal antibody immune checkpoint inhibitor (BAT1308, a PD-1 inhibitor) with two cytotoxic chemotherapeutic agents—**carboplatin** (a platinum-based DNA crosslinker) and **paclitaxel** (a microtubule stabilizer). BAT1308 is developed as a recombinant monoclonal antibody targeting the PD-1 receptor to reactivate anti-tumor immunity. The combination is under evaluation as first-line therapy for advanced or metastatic solid tumors, including but not limited to non-small cell lung cancer and cervical cancer, generally in patients with PD-L1 positive tumors. Studies indicate this regimen shows durable antitumor activity with a manageable safety profile, especially used as first-line therapy in certain cancers[3][4].

Other names
BAT1308 plus carboplatin plus paclitaxelBAT-1308 plus carboplatin plus paclitaxelBAT 1308 plus carboplatin plus paclitaxel
02

Targets

PDCD1 (Programmed cell death protein 1 receptor)DNATUBB (Tubulin (alpha and beta subunits))

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