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BAT4706 + BAT1308

Development stage: Unknown
Lead developer: Bio-Thera Solutions
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

BAT4706 + BAT1308 is a combination of two monoclonal antibody drugs developed for the treatment of advanced solid tumors. BAT1308 is a humanized monoclonal antibody against programmed cell death protein 1 (PD-1), functioning as an immune checkpoint inhibitor[3]. BAT4706 is an all-human IgG1 monoclonal antibody candidate, optimized by non-fucosylation, targeting cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)[3]. Together, these drugs act by dual blockade of PD-1 and CTLA-4, potentiating anti-tumor immune responses. The combination is under evaluation in Phase 1 clinical trials to assess safety, tolerability, pharmacokinetics, and preliminary efficacy in patients with advanced solid tumors[1][2][5][6].

Other names: BAT4706 + BAT1308

Targets

PDCD1 (Programmed cell death protein 1 receptor)CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)

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