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baxdrostat + dapagliflozin
- Development stage
- Unknown
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Baxdrostat + dapagliflozin is an investigational fixed-dose oral combination therapy currently in Phase 3 clinical trials for chronic kidney disease (CKD) and hypertension, as well as heart failure. Baxdrostat is a highly selective, oral small molecule inhibitor of aldosterone synthase (CYP11B2), which reduces aldosterone production without affecting cortisol synthesis. Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that lowers blood glucose and provides renal and cardiovascular protection. The combination aims to slow CKD progression and reduce cardiovascular events by targeting both aldosterone-mediated pathways and SGLT2-mediated glucose/sodium reabsorption[1][2][3][5][6].
- Other names
- baxdrostat/dapagliflozin
02
Targets
CYP11B2 (Cytochrome P450 11B2)SGLT2 (Sodium-glucose cotransporter protein subunit 2)
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