baxdrostat + itraconazole

Baxdrostat + itraconazole refers to the concomitant use of baxdrostat, a selective aldosterone synthase inhibitor, and itraconazole, an antifungal agent and potent CYP3A4 inhibitor. This combination has been evaluated in phase 1 pharmacokinetic studies to assess how itraconazole affects the metabolism and exposure of baxdrostat in humans. Baxdrostat lowers blood pressure by inhibiting aldosterone synthesis via targeting cytochrome P-450 CYP11B2 (aldosterone synthase). Itraconazole inhibits fungal cell membrane synthesis but is not used here for its antifungal properties—instead, it serves as a strong CYP3A4 inhibitor to model drug-drug interaction potential for baxdrostat.