BAY1753011 + furosemide

BAY1753011 + furosemide is a combination of a novel, dual-acting vasopressin receptor antagonist (BAY1753011) and the loop diuretic furosemide. **BAY1753011** targets both V1a and V2 vasopressin receptors, blocking vasopressin-induced water retention and vasoconstriction, as well as exerting antifibrotic and antihypertrophic effects. **Furosemide** is a potent loop diuretic, commonly used for the treatment of hypertension and edema associated with conditions such as congestive heart failure, cirrhosis, and renal disease, acting through inhibition of sodium-potassium-chloride cotransport in the nephron. The combination aims for **decongestion and vascular protection in heart failure** while limiting the activation of the renin-angiotensin system, exploiting both diuretic and vasopressin antagonism mechanisms[1][2][3].

Brand names

Lasix

Other names

furosemide