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bazedoxifene + cholecalciferol
- Development stage
- Unknown
- Lead developer
- Huons
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Bazedoxifene + cholecalciferol is a fixed-dose combination of two active ingredients: bazedoxifene, a third-generation selective estrogen receptor modulator (SERM), and cholecalciferol, also known as vitamin D3. Bazedoxifene acts as an estrogen receptor agonist or antagonist depending on the tissue type, decreasing bone resorption and increasing bone mineral density by reducing biochemical markers of bone turnover. Cholecalciferol is a form of vitamin D that helps regulate calcium and phosphate homeostasis, supporting healthy bone formation. This combination is being developed primarily for the treatment and prevention of postmenopausal osteoporosis[8][5][3]. The product has been studied in clinical trials for its pharmacokinetics and tolerability in healthy volunteers[5].
- Brand names
- Hubon
- Other names
- bazedoxifene acetate + cholecalciferol
02
Targets
ESR2 (ERβ)VDR (Vitamin D receptor)ESR1 (ERα)
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