beclomethasone + zileuton

Beclomethasone + zileuton is a combination therapy consisting of two active pharmaceutical ingredients used in the management of asthma. Beclomethasone is an inhaled synthetic glucocorticoid corticosteroid that acts as an anti-inflammatory agent by binding to the glucocorticoid receptor, thereby reducing airway inflammation and hyperresponsiveness. Zileuton is a small molecule inhibitor of 5-lipoxygenase (5-LO), an enzyme involved in leukotriene synthesis; by inhibiting this pathway, zileuton reduces leukotriene-mediated bronchoconstriction and inflammation. The combination has been studied as an alternative to increasing inhaled corticosteroid doses for patients with persistent asthma symptoms not controlled on low-dose inhaled corticosteroids alone[1][3][5]. Clinical studies suggest that adding zileuton to low-dose beclomethasone may provide similar improvements in lung function and symptom control compared to doubling the dose of beclomethasone, offering another option for patients who require additional asthma control[1].