Drug intelligence / Profile preview

beclomethasone dipropionate + ipratropium bromide + salbutamol

Development stage
Unknown
Lead developer
GSK
Modality
Inhalation Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules
Administration
Inhalation
01

Overview

This is a triple combination therapy used primarily for respiratory conditions. It combines: 1. Beclomethasone dipropionate - an inhaled corticosteroid with anti-inflammatory properties 2. Ipratropium bromide - a short-acting muscarinic antagonist (SAMA) that acts as a bronchodilator 3. Salbutamol (also known as albuterol) - a short-acting beta-2 agonist (SABA) that provides rapid bronchodilation This combination targets multiple mechanisms involved in respiratory conditions, particularly asthma and chronic obstructive pulmonary disease (COPD). The corticosteroid component (beclomethasone) reduces airway inflammation, while the two bronchodilators (ipratropium and salbutamol) work through different mechanisms to relax bronchial smooth muscle and improve airflow[1][2][6]. Studies have shown that combining these medications can be more effective than individual components alone, particularly in patients with moderate to severe asthma exacerbations[2][6]. The combination of ipratropium and salbutamol has been demonstrated to reduce hospitalization rates compared to salbutamol alone, especially in severe cases[2].

Other names
beclomethasone + ipratropium + albuterol
02

Targets

GR (Glucocorticoid receptor)ADRB2 (β2)mAChR (Muscarinic acetylcholine receptors)

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