Drug intelligence / Profile preview

bedaquiline + clofazimine + linezolid + XY

Development stage
Preclinical
Lead developer
Janssen Pharmaceutical
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

This appears to be a combination of anti-tuberculosis drugs including bedaquiline, clofazimine, and linezolid, with an unknown fourth component labeled as "XY". The first three components are used in combination regimens for treating multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). Bedaquiline is a diarylquinoline that inhibits mycobacterial ATP synthase. Clofazimine is a riminophenazine compound with antimycobacterial properties. Linezolid is an oxazolidinone antibiotic that inhibits protein synthesis. Without identification of the "XY" component, the complete mechanism of action and efficacy of this specific combination cannot be determined.

02

Targets

ATP SynthaseBacterial 50S ribosomal subunitbc1 complex (Cytochrome bc1 complex (plasmodium))

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