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befiradol (18F)
- Development stage
- Phase 2
- Lead developer
- Neurolixis
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
Befiradol (18F), also known as [18F]F15599, is a radiopharmaceutical PET (Positron Emission Tomography) tracer and a highly selective agonist for the serotonin 5-HT1A receptor. It is specifically designed to bind with high affinity to the G-protein-coupled (active) state of the 5-HT1A receptor, providing a functional measure of receptor density and activity in the brain. Developed originally by Pierre Fabre and currently utilized in clinical research by institutions such as Hospices Civils de Lyon, befiradol (18F) is used to investigate the neurobiology of conditions such as episodic cluster headache and major depressive disorder. By targeting the high-affinity state, it offers superior sensitivity compared to traditional 5-HT1A antagonists in detecting changes in serotonergic signaling within regions like the hypothalamus and raphe nuclei, which are critical in the pathophysiology of headache disorders.
- Other names
- 18F-befiradol[18F]-F15599
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))
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