bempedoic acid + atorvastatin

The combination of **bempedoic acid** and **atorvastatin** is a co-administration of two lipid-lowering small molecules used primarily in patients with hypercholesterolemia who require additional LDL cholesterol (LDL-C) lowering beyond what is achievable with statin therapy alone. **Bempedoic acid** is an adenosine triphosphate-citrate lyase (ACL) inhibitor that reduces cholesterol synthesis upstream of HMG-CoA reductase, the target of statins. **Atorvastatin**, a statin, inhibits HMG-CoA reductase, blocking a later step in cholesterol production. Used together, they can achieve greater LDL-C reduction than either alone, and may allow for lower statin dosing to avoid adverse effects while maintaining efficacy. This combination is under investigation and may be used alongside other lipid-lowering agents such as ezetimibe in high-risk populations[1][3][5][7].

Other names

bempedoic acid/atorvastatin fixed-dose combination