Drug intelligence / Profile preview

benazepril + valsartan + fluvastatin

Development stage
Preclinical
Lead developer
Novartis
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination drug consisting of benazepril, valsartan, and fluvastatin. Benazepril is an angiotensin-converting enzyme (ACE) inhibitor used primarily for hypertension and heart failure. Valsartan is an angiotensin II receptor blocker (ARB) also indicated for hypertension, heart failure, and post-myocardial infarction management[4]. Fluvastatin is a statin that inhibits HMG-CoA reductase to lower cholesterol levels. The rationale for combining these agents lies in their complementary mechanisms targeting both blood pressure regulation (via the renin-angiotensin system) and lipid lowering (via statin therapy). Clinical studies have shown that combinations such as benazepril with fluvastatin or valsartan with fluvastatin may improve outcomes in patients with atrial fibrillation or cardiovascular risk factors by reducing arrhythmia burden, improving vascular function, and providing additive benefits on blood pressure and lipid profiles[1][2][3][5]. However, there are no reports of a fixed-dose triple combination product containing all three drugs; this description refers to the concurrent use of these agents.

Other names
ACE I + ATA II + StatinsRemission Clinic protocolMultimodal nephroprotection regimen
02

Targets

ACE (Angiotensin Converting Enzyme)AGTR1 (Angiotensin II Type-1 receptor)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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