benzonatate + guaifenesin

**Benzonatate + guaifenesin** is a combination of two small-molecule drugs used for symptomatic relief of cough and associated lung congestion. Benzonatate is a non-narcotic antitussive that acts as a local anesthetic on the stretch receptors in the lungs, pleura, and respiratory passages, thereby suppressing the cough reflex without central nervous system depression. Guaifenesin is an expectorant that increases the volume and reduces the viscosity of bronchial secretions, facilitating their expulsion. This oral combination, often formulated in capsules or extended-release forms (e.g., 100 mg benzonatate + 200-400 mg guaifenesin per dose, up to 4 times daily), provides complementary antitussive and mucolytic effects for acute respiratory conditions like colds, bronchitis, or flu-related cough with congestion.[1][2][3][5]