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benzoyl peroxide + tretinoin
- Development stage
- Approved
- Lead developer
- Sol-Gel Technologies
- Modality
- Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
- Administration
- Topical
01
Overview
A fixed-dose topical combination of microencapsulated benzoyl peroxide (3%) and microencapsulated tretinoin (0.1%), developed for the treatment of acne vulgaris. Benzoyl peroxide acts as an anti-infective and oxidant with keratolytic properties, while tretinoin is a retinoid that functions as a retinoic acid receptor agonist to modulate epithelial cell growth and differentiation. The formulation uses Sol-Gel Technologies' proprietary microencapsulation technology to enhance stability and tolerability. The product is marketed under the brand name Twyneo for use in patients aged 9 years and older[1][2][3].
- Brand names
- TwyneoTWIN
- Other names
- microencapsulated benzoyl peroxide 3% and microencapsulated tretinoin 0.1% creamtretinoin/benzoyl-peroxide
02
Targets
RAR (Retinoic acid receptor)
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