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benzydamine hydrochloride + chlorhexidine gluconate
- Development stage
- Unknown
- Lead developer
- Osko
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
GERAKS is a fixed-dose combination oral topical product containing the antiseptic chlorhexidine gluconate (0.12%) and the non-steroidal anti-inflammatory drug (NSAID) benzydamine hydrochloride (0.15%). Developed by Osko, it is indicated for the treatment of oral mucosal conditions, including mouth ulcers, gingivitis, and general oral irritation. Benzydamine provides local analgesic and anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines such as TNF-alpha and IL-1beta, while chlorhexidine acts as a broad-spectrum antimicrobial agent by disrupting microbial cell membranes. The product is available in both oral spray and mouthwash formulations for direct application to the oral mucosa.
- Brand names
- GERAKSGERAKS Oral SprayGERAKS Mouthwash
- Other names
- benzydamine/chlorhexidine
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)
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