benzylpenicillin + gentamicin

Benzylpenicillin (Penicillin G) and gentamicin is an antibiotic combination that provides synergistic activity against various bacterial infections. Benzylpenicillin is a natural penicillin that inhibits bacterial cell wall synthesis, while gentamicin is an aminoglycoside that inhibits protein synthesis in susceptible bacteria. This combination is particularly effective against group D streptococci, including Streptococcus faecalis (Enterococcus faecalis), and is commonly used for empirical treatment of neonatal sepsis, bacterial meningitis, and other serious infections. The synergistic effect occurs as penicillin increases bacterial cell wall permeability, facilitating gentamicin's access to its target site within the bacterial cell.

Other names

Penicillin G + gentamicin