Drug intelligence / Profile preview

beraprost + spherical carbon adsorbent

Development stage
Unknown
Lead developer
Kaken Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Beraprost + spherical carbon adsorbent is a combination product comprising beraprost, an orally active synthetic prostacyclin analogue, and spherical carbon adsorbent, a non-absorbed oral carbon compound designed to bind toxins and certain metabolites in the gastrointestinal tract. **Beraprost** acts primarily as a vasodilator and inhibits platelet aggregation via selective agonist activity at the prostacyclin (IP) receptor, thus improving vascular conditions such as pulmonary arterial hypertension, peripheral artery disease, and Buerger’s disease. The **spherical carbon adsorbent** functions as a gastrointestinal adsorbent to reduce absorption of toxic metabolites and uremic toxins, utilized in chronic kidney disease and related conditions. The rationale for this combination may target patients with vascular complications (such as diabetic nephropathy or chronic kidney disease) where both vascular protection and gastrointestinal detoxification are sought, though this specific combination does not correspond to a widely recognized or globally approved fixed combination product.

02

Targets

PTGIR (Prostanoid IP Receptor)UTs (Gastrointestinal uremic toxins)PTGER4 (Prostaglandin E2 receptor EP4 subtype)

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