berberine + alpha lipoic acid + picrorhiza

This is a combination dietary supplement containing **berberine**, **alpha-lipoic acid**, and **picrorhiza**. It is being studied under the name CAR-191 for its effects on appetite suppression, body composition, and weight control, as well as on the mechanistic effects of oxidation, inflammation, and vascular function, particularly in high-risk populations with metabolic syndrome[1][4]. Each active ingredient is administered in separate capsules (berberine 200 mg, alpha-lipoic acid 150 mg, picrorhiza 100 mg) taken three times daily before meals[1][4]. - **Berberine** acts via modulation of hepatic low-density lipoprotein receptor expression, improvement of endothelial function, and reduction in LDL cholesterol and glucose[5][7][9]. - **Alpha-lipoic acid** functions as an antioxidant and has demonstrated efficacy in improving diabetic neuropathy and reducing blood lipids[2][8]. - **Picrorhiza** is used in traditional medicine, primarily for liver-related disorders, and may have immunomodulatory and glucose-lowering properties[3][6]. The supplement is currently at the clinical investigation stage and is not an approved pharmaceutical[1][4].

Brand names

CAR-191CAR191CAR 191

Other names

berberine + alpha-lipoic acid + picrorhiza