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berotralstat + digoxin
- Development stage
- Unknown
- Lead developer
- BioCryst Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Berotralstat (BCX7353) is a synthetic small molecule oral inhibitor of plasma kallikrein developed for the prophylactic treatment of hereditary angioedema (HAE). It works by binding to and inhibiting plasma kallikrein activity in the kallikrein-kinin system to reduce bradykinin production and prevent HAE attacks. Digoxin is a cardiac glycoside derived from digitalis plant leaves. It increases myocardial contractility (positive inotropic effect) and decreases heart rate (negative chronotropic effect), making it useful for treating mild to moderate heart failure and controlling ventricular response rate in chronic atrial fibrillation[1][5][6][8].
- Brand names
- OrladeyoDigitekDigoxLanoxinLanoxicapsCardoxin
- Other names
- berotralstatBCX7353BCX-7353BCX 7353digoxin
02
Targets
ATP1A (Sodium/potassium-transporting ATPase)ABCB1 (P-glycoprotein)KLKB1 (Plasma kallikrein)
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