beta-(2-naphthyl)-alanine

Beta-(2-Naphthyl)-Alanine is a synthetic, non-proteinogenic amino acid derivative characterized by the presence of a naphthalene ring attached to the β-carbon of alanine. It exists in both L and D enantiomeric forms. The compound is primarily used as a building block in peptide synthesis, where its bulky aromatic side chain can modulate peptide structure and function. In research settings, it has been studied for its ability to inhibit peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), as well as prothrombin, suggesting potential utility in modulating protein folding and coagulation pathways[1][8]. Its hydrophobicity and steric properties make it valuable for designing peptides with enhanced stability or altered biological activity. Beta-(2-Naphthyl)-Alanine has also been explored as a fluorescent probe in receptor studies due to its aromatic moiety[8].

Other names

2-naphthylalaninebeta-naphthylalanine(S)-2-amino-3-(naphthalen-2-yl)propanoic acid(R)-2-amino-3-(naphthalen-2-yl)propanoic acidL-beta-(2-naphthyl)alanineD-beta-(2-naphthyl)alanine