beta 1,3-1,6 glucan

Beta 1,3-1,6 glucan is a naturally occurring polysaccharide derived from the cell wall of the black yeast *Aureobasidium pullulans*. Developed by Nichi Glucan and GN Corporation, it functions as an immunomodulatory adjuvant and biological response modifier. The compound is primarily utilized as a dietary supplement to support immune function in various conditions. Specifically, the **Neu-REFIX** formulation has received FDA Orphan Drug Designation and Rare Pediatric Disease Designation for the treatment of Duchenne Muscular Dystrophy (DMD), where it is investigated for its ability to modulate inflammation and potentially slow disease progression. The **Nichi Brite** formulation is used as a supportive adjuvant in patients with gastrointestinal and hepatobiliary cancers, including pancreatic and bile duct cancers. Its mechanism involves the activation of innate immune cells such as macrophages and natural killer (NK) cells.

Brand names

Neu-REFIXNichi Brite

Other names

Aureobasidium pullulans beta-glucanNichi Glucan