Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
betamethasone + 5-fluorouracil
- Development stage
- Unknown
- Lead developer
- Central Hospital Affiliated to Shandong First Medical University
- Modality
- Small Molecules
- Administration
- Intralesional
01
Overview
Betamethasone + 5-fluorouracil is a combination therapy consisting of the synthetic glucocorticoid betamethasone and the antimetabolite 5-fluorouracil. It is primarily used as an intralesional injection for the treatment of keloids and hypertrophic scars. Betamethasone acts by suppressing inflammation and inhibiting collagen synthesis through glucocorticoid receptor activation, while 5-fluorouracil inhibits fibroblast proliferation and TGF-beta-induced collagen expression by interfering with DNA synthesis via thymidylate synthase inhibition. This synergistic approach helps reduce the volume and recurrence rate of keloids, which are often resistant to monotherapy.
- Other names
- 5-fluorouracil + betamethasone5-FU + betamethasone
02
Targets
GR (Glucocorticoid receptor)RNAP (Bacterial dna-dependent RNA polymerase)TS (Thymidylate synthase)
Beyond the preview
Go deeper on betamethasone + 5-fluorouracil.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on betamethasone + 5-fluorouracil.