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betamethasone + 5-fluorouracil
- Development stage
- Unknown
- Lead developer
- Central Hospital Affiliated to Shandong First Medical University
- Modality
- Small Molecules
- Administration
- Intralesional
01
Overview
Betamethasone + 5-fluorouracil is a combination therapy consisting of the synthetic glucocorticoid betamethasone and the antimetabolite 5-fluorouracil. It is primarily used as an intralesional injection for the treatment of keloids and hypertrophic scars. Betamethasone acts by suppressing inflammation and inhibiting collagen synthesis through glucocorticoid receptor activation, while 5-fluorouracil inhibits fibroblast proliferation and TGF-beta-induced collagen expression by interfering with DNA synthesis via thymidylate synthase inhibition. This synergistic approach helps reduce the volume and recurrence rate of keloids, which are often resistant to monotherapy.
- Other names
- 5-fluorouracil + betamethasone5-FU + betamethasone
02
Targets
RNAP (Bacterial dna-dependent RNA polymerase)GR (Glucocorticoid receptor)TS (Thymidylate synthase)
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