Drug intelligence / Profile preview

betamethasone dipropionate + gentamicin sulfate

Development stage
Unknown
Lead developer
Organon
Modality
Small Molecules
Administration
Topical
01

Overview

Begent Cream is a topical combination dermatological preparation containing the synthetic corticosteroid betamethasone dipropionate and the aminoglycoside antibiotic gentamicin sulfate. Betamethasone dipropionate is a highly potent glucocorticoid that exerts anti-inflammatory, antipruritic, and vasoconstrictive effects by binding to glucocorticoid receptors and inhibiting inflammatory transcription factors. Gentamicin sulfate is a broad-spectrum antibiotic that binds to the 30S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis and exerting bactericidal activity. Begent Cream is developed by Global Pharmaceuticals and is indicated for the treatment of inflammatory skin conditions, such as eczema, psoriasis, and dermatitis, that are complicated by or at risk of secondary bacterial infections.

Brand names
BegentDigentaDiprogenta
Other names
betamethasone dipropionate + gentamicin sulfatebetamethasone dipropionate + gentamicin sulphatebetamethasone dipropionate 0.064% + gentamicin sulphate 1.7mg/gbetamethasone dipropionate 0.064%, gentamicin sulphate 1.7mg/g
02

Targets

GR (Glucocorticoid receptor)LRP2 (Low-density lipoprotein receptor-related protein 2)Bacterial Ribosome

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