betrixaban + amiodarone

**Betrixaban + amiodarone** is a combination of two pharmaceutical agents: *betrixaban*, a direct oral anticoagulant (DOAC) that inhibits coagulation factor Xa, and *amiodarone*, a class III antiarrhythmic that blocks multiple cardiac ion channels and inhibits cytochrome P450 enzymes and permeability glycoprotein (P-gp). The combination is not available as a fixed-dose product but refers to concurrent administration, usually in patients requiring both anticoagulation (for venous thromboembolism prophylaxis) and rhythm control. Amiodarone increases betrixaban plasma exposure by inhibiting P-gp, thus increasing bleeding risk—especially in patients with renal impairment—so dose reduction or combination avoidance is recommended in such populations[1][2][5].

Brand names

BEVYXXA (for betrixaban)amiodarone (no unique brand provided for combination)

Other names

betrixaban + amiodarone